2080 Ventures · Investor guides
72 Deep Tech & Hard Science VC firms in United States
Compare 72 Deep Tech & Hard Science VC firms in United States, including 1517 Fund, 8VC, Afore Capital. Explore focus areas, stages and published contacts with 2080 Ventures.
72matching directory firms
30published contacts
25headquarters specified
Most frequent stage tags in this selection: Seed (65), Pre-Seed (63), Early Stage (45). These counts describe this directory, not total market activity.
Compare Deep Tech & Hard Science VC firms in United States
Use this comparison to check fit before contacting a firm. Country tags describe reported locations or country-list membership; they do not establish where a firm is willing to invest.
| Firm | Location | Focus | Stage | Website |
|---|---|---|---|---|
 1517 Fund | United States | Climate & Sustainability, Consumer, Deep Tech & Hard Science, Education | Convertible Note, Early Stage, Pre-Seed, Seed | 1517fund.com |
 8VC | San Francisco, California, United States | AI & ML, Biotech, Consumer, Deep Tech & Hard Science | Early Stage, Late Stage, Pre-Seed, Seed | 8vc.com |
 Afore Capital | San Francisco, California, United States | AI & ML, AR & VR, Automotive, Big Data & Analytics | Early Stage, Late Stage, Pre-Seed, Seed | afore.vc |
 AME Cloud Ventures | Palo Alto, California, United States | AI & ML, Deep Tech & Hard Science, Fintech, Government Technology | Any, Early Stage, Late Stage, Seed | amecloudventures.com |
 Andreessen Horowitz | Menlo Park, California, United States | AI & ML, AR & VR, Advertising, Agriculture | Early Stage, Late Stage, Pre-Seed, Seed | a16z.com |
 Autotech Ventures | Menlo Park, California, United States | AI & ML, Automotive, Deep Tech & Hard Science, Enterprise | Early Stage, Late Stage, Pre-Seed, Seed | autotechvc.com |
 Bain Capital Ventures | San Francisco, California, United States | AI & ML, API, Advertising, Automotive | Early Stage, Late Stage, Pre-Seed, Seed | baincapitalventures.com |
 Basis Set Ventures | Menlo Park, California, United States | AI & ML, API, Automation, Automotive | Early Stage, Late Stage, Pre-Seed, Seed | basisset.com |
 Boost VC | San Mateo, California, United States | AI & ML, AR & VR, Advertising, Aerospace & Space | Early Stage, Pre-Seed, Seed | boost.vc |
 BoxGroup | New York, New York, United States | AI & ML, Big Data & Analytics, Climate & Sustainability, Consumer | Early Stage, Pre-Seed, Seed, Series A | boxgroup.com |
 Caffeinated Capital | San Francisco, California, United States | Agriculture, Chemicals, Climate & Sustainability, Consumer | Convertible Note, Early Stage, Late Stage, Pre-Seed | caffeinatedcapital.com |
 Cultivation Capital | St Louis, Missouri, United States | Agriculture, Big Data & Analytics, Cybersecurity, Deep Tech & Hard Science | Convertible Note, Debt, Early Stage, Growth | cultivationcapital.com |
 DCVC | Palo Alto, California, United States | AI & ML, Aerospace & Space, Agriculture, Climate & Sustainability | Early Stage, Seed, Series A | dcvc.com |
 First Round Capital | Philadelphia, Pennsylvania, United States | AI & ML, Advertising, Big Data & Analytics, Biotech | Debt, Early Stage, Late Stage, Pre-Seed | firstround.com |
 GoAhead Ventures | Menlo Park, California, United States | AI & ML, AR & VR, Automotive, Climate & Sustainability | Early Stage, Pre-Seed, Seed | goaheadvc.com |
 Kleiner Perkins | Menlo Park, California, United States | AI & ML, Advertising, Big Data & Analytics, Cloud | Early Stage, Late Stage, Pre-Seed, Private Equity | kleinerperkins.com |
 Lux Capital | New York, New York, United States | AI & ML, AR & VR, Aerospace & Space, Big Data & Analytics | Debt, Early Stage, Late Stage, Pre-Seed | luxcapital.com |
 Nexus Venture Partners | Menlo Park, California, United States | AI & ML, Big Data & Analytics, Biotech, Climate & Sustainability | Early Stage, Pre-Seed, Seed, Series A | nexusvp.com |
 One Way Ventures | Boston, Massachusetts, United States | AI & ML, Automotive, Big Data & Analytics, Climate & Sustainability | Convertible Note, Debt, Early Stage, Late Stage | onewayvc.com |
 Pear VC | Menlo Park, California, United States | AI & ML, Automotive, Big Data & Analytics, Biotech | Convertible Note, Early Stage, Late Stage, Pre-Seed | pear.vc |
 SOSV | Princeton, New Jersey, United States | AI & ML, Advertising, Agriculture, Big Data & Analytics | Early Stage, Growth, Pre-Seed, Seed | sosv.com |
 Spark Capital | San Francisco, California, United States | AI & ML, AR & VR, Consumer, Creator Economy | Debt, Early Stage, Late Stage, Pre-Seed | sparkcapital.com |
 Trinity Ventures | Menlo Park, California, United States | Advertising, Big Data & Analytics, Cloud, Consumer | Early Stage, Late Stage, Pre-Seed, Seed | trinityventures.com |
 Backstage Capital | Los Angeles, California, United States | AI & ML, AR & VR, Automotive, Big Data & Analytics | Convertible Note, Early Stage, Late Stage, Pre-Seed | backstagecapital.com |
 First Star Ventures | United States | AI & ML, Big Data & Analytics, Climate & Sustainability, Consumer | Early Stage, Pre-Seed, Seed | firststar.vc |
 Fusion Fund | United States | AI & ML, Automotive, Big Data & Analytics, Consumer | Early Stage, Late Stage, Pre-Seed, Seed | fusionfund.com |
 Gaingels | Burlington, Vermont, United States | AI & ML, Agriculture, Biotech, Climate & Sustainability | Early Stage, Late Stage, Pre-Seed, Seed | gaingels.com |
 HG Ventures | United States | AI & ML, Chemicals, Climate & Sustainability, Construction | Early Stage, Growth, Initial Coin Offering, Late Stage | hgventures.com |
 Link Ventures | United States | AI & ML, Deep Tech & Hard Science, Enterprise, SaaS | Convertible Note, Debt, Early Stage, Late Stage | linkventures.com |
 Playground Global | Palo Alto, California, United States | AI & ML, Aerospace & Space, Automation, Biotech | Early Stage, Seed, Series A, Series B | playground.vc |
 Upfront Ventures | United States | AI & ML, Advertising, Big Data & Analytics, Biotech | Debt, Early Stage, Late Stage, Pre-Seed | upfront.com |
 REMUS Capital | United States | AI & ML, Agriculture, Climate & Sustainability, Consumer | Early Stage, Pre-Seed, Seed | remuscap.com |
 Acadian Ventures | United States | Biotech, Consumer, Deep Tech & Hard Science, Enterprise | Pre-Seed, Seed | acadianventures.com |
 Access Venture Partners | United States | AI & ML, Aerospace & Space, Automation, Consumer | Pre-Seed, Seed, Series A | accessvp.com |
 Access Ventures | United States | AI & ML, Aerospace & Space, Automation, Consumer | Debt, Series A | accessventures.org |
 Activate Venture Partners | United States | AI & ML, Climate & Sustainability, Cloud, Cybersecurity | Pre-Seed, Seed, Series A | activatevp.com |
 AlleyCorp | United States | AI & ML, Agriculture, Climate & Sustainability, Construction | Pre-Seed, Seed | alleycorp.com |
 Ascension Ventures | United States | AI & ML, Big Data & Analytics, Biotech, Climate & Sustainability | Pre-Seed, Seed, Series A | ascensionventures.org |
 AV8 Ventures | United States | AI & ML, Big Data & Analytics, Deep Tech & Hard Science, Developer Tools | Pre-Seed, Seed, Series A | av8.vc |
 Brickyard | United States | AI & ML, Agriculture, Construction, Consumer | Pre-Seed, Seed | justlaybrick.com |
 Calibrate Ventures | United States | AI & ML, Agriculture, Automation, Deep Tech & Hard Science | Pre-Seed, Seed, Series A | calibratevc.com |
 Celesta Capital | United States | AI & ML, Automotive, Big Data & Analytics, Biotech | Early Stage, Late Stage, Pre-Seed, Seed | celesta.vc |
 Compound | United States | AI & ML, AR & VR, Big Data & Analytics, Biotech | Pre-Seed | compound.vc |
 E1 Ventures | United States | AI & ML, Biotech, Deep Tech & Hard Science, Defense Technology | Early Stage, Late Stage, Pre-Seed, Seed | e1.vc |
 Eniac Ventures | United States | AI & ML, AR & VR, Advertising, Big Data & Analytics | Pre-Seed, Seed | eniac.vc |
 Fifty Years | United States | Agriculture, Biotech, Chemicals, Climate & Sustainability | Late Stage, Pre-Seed, Seed | fiftyyears.com |
 Floodgate | United States | Biotech, Consumer, Creator Economy, Crypto & Blockchain | Early Stage, Late Stage, Pre-Seed, Seed | floodgate.com |
 Greylock | United States | AI & ML, Consumer, Crypto & Blockchain, Deep Tech & Hard Science | Early Stage, Late Stage, Pre-Seed, Seed | greylock.com |
 Hack VC | United States | AI & ML, Cloud, Consumer, Deep Tech & Hard Science | Early Stage, Late Stage, Pre-Seed, Seed | hack.vc |
 Heavybit | United States | Big Data & Analytics, Climate & Sustainability, Cloud, Cybersecurity | Late Stage, Pre-Seed, Seed, Series A | heavybit.com |
 HOF Capital | United States | AI & ML, AR & VR, Cloud, Consumer | Early Stage, Late Stage, Pre-Seed, Seed | hofcapital.com |
 Innovation Endeavors | United States | AI & ML, Advertising, Agriculture, Big Data & Analytics | Late Stage, Pre-Seed, Seed | innovationendeavors.com |
 Lockheed Martin Ventures | United States | AI & ML, AR & VR, Cybersecurity, Deep Tech & Hard Science | Early Stage, Pre-Seed | lockheedmartin.com |
 Lowercarbon Capital | United States | Agriculture, Biotech, Chemicals, Climate & Sustainability | Early Stage, Late Stage, Pre-Seed, Seed | lowercarboncapital.com |
 Meridian Street Capital | United States | AI & ML, Deep Tech & Hard Science, Diagnostics, Health & Wellness | Debt, Pre-Seed | meridianstreetcapital.com |
 New Stack Ventures | United States | Cloud, Consumer, Cybersecurity, Deep Tech & Hard Science | Pre-Seed, Seed | newstack.com |
 Ocean Azul Partners | United States | AI & ML, Agriculture, Biotech, Cybersecurity | Pre-Seed, Seed, Series A | oceanazulpartners.com |
 Qbic Fund | Belgium, United States | Biotech, Deep Tech & Hard Science, Healthcare, SaaS | Not listed | qbic.be |
 Quiet Capital | United States | AI & ML, Advertising, Big Data & Analytics, Biotech | Early Stage, Late Stage, Pre-Seed, Seed | quiet.com |
 Rosecliff Ventures | United States | AI & ML, Cloud, Cybersecurity, Deep Tech & Hard Science | Debt, Pre-Seed, Seed | rosecliff.com |
 SeaX Ventures | United States | AI & ML, Agriculture, Biotech, Climate & Sustainability | Early Stage, Pre-Seed, Seed | seaxventures.vc |
 Serena Ventures | United States | AI & ML, Big Data & Analytics, Cloud, Deep Tech & Hard Science | Early Stage, Late Stage, Pre-Seed, Seed | serenaventures.com |
 Service Provider Capital | United States | Big Data & Analytics, Consumer, Crypto & Blockchain, Cybersecurity | Series A | serviceprovidercapital.com |
 SignalFire | United States | AI & ML, Big Data & Analytics, Chemicals, Cloud | Early Stage, Late Stage, Pre-Seed, Seed | signalfire.com |
 Social Capital | United States | Climate & Sustainability, Crypto & Blockchain, Deep Tech & Hard Science, Enterprise | Seed | socialcapital.com |
 Third Sphere | United States | AI & ML, Agriculture, Climate & Sustainability, Construction | Debt, Early Stage, Pre-Seed, Seed | thirdsphere.com |
 Tuesday Capital | United States | AI & ML, Automation, Big Data & Analytics, Climate & Sustainability | Seed | tuesday.vc |
 UpHonest Capital | United States | AI & ML, Big Data & Analytics, Cloud, Consumer | Debt, Pre-Seed, Seed, Series A | uphonestcapital.com |
 UpWest | United States | AI & ML, Cloud, Cybersecurity, Deep Tech & Hard Science | Late Stage, Pre-Seed, Seed | upwest.vc |
 Walden Catalyst | United States | AI & ML, Biotech, Cloud, Deep Tech & Hard Science | Not listed | waldencatalyst.com |
 XFactor Ventures | United States | AI & ML, Agriculture, Cloud, Consumer | Pre-Seed, Seed | xfactor.ventures |
 Outpost Ventures | United States | AI & ML, Big Data & Analytics, Cybersecurity, Deep Tech & Hard Science | Debt, Pre-Seed, Seed | outpostventures.vc |
Build an outreach list that fits your company
Map technical milestones to capital requirements. Explain validation, defensibility, development timelines, and the resources needed to move from prototype to commercial deployment.
For United States, confirm location eligibility before preparing a full pitch: where must the company be incorporated, where should the team operate, and does the investor back companies expanding into the market? A local office alone does not answer those questions.
- Check the mandate. Confirm sector, stage, geography, check size, and whether the firm leads or follows rounds.
- Find the relevant partner. Read current team profiles and recent investments before asking for an introduction.
- Make the fit specific. Explain your product, customer evidence, round size, and why this firm is a match.
- Use the correct submission route. A general office contact may not accept investment pitches. Look for a current pitch form or a partner’s published instructions.
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How these guides are compiled. Directory labels may include source-list classifications. Confirm current activity and investment preferences directly with the firm.